Research, all articles

Age related macular degeneration (AMD) is the leading cause of severe visual loss in people aged over 50 in the developed world. Early AMD is characterised clinically by yellow deposits known as drusen and changes in pigmentation of the retina. Late AMD develops when there is an ingrowth...

Background Choline, an essential nutrient, is present in human milk and important for brain function. Adequate intakes (AIs) for choline were established by the IOM in 1998, but nationally representative estimates of intake are limited. Objective To assess intakes and sources of choline in...

Objective To estimate choline intakes of US subpopulations including children, men, women and pregnant women. Background Choline is an essential nutrient which plays critical roles in brain development and homocysteine metabolism. Choline is widely distributed in foods; good sources...

Lutein and zeaxanthin accumulate in the macular pigment of the retina, and are associated with a reduced incidence of macular degeneration. The objective of the study was to investigate the effect of consuming 1 egg/d for 5-wk on the serum concentrations of lutein, zeaxanthin, lipids and...

Choline is a required nutrient, and some humans deplete quickly when fed a low-choline diet, whereas others do not. Endogenous choline synthesis can spare some of the dietary requirement and requires one-carbon groups derived from folate metabolism. We examined whether major genetic...

Choline is a dietary component essential for normal function of all cells. In 1998 the National Academy of Sciences, USA, issued a report identifying choline as a required nutrient for humans and recommended daily intake amounts. In ongoing studies we are finding that men have a higher...

Background: Dietary protein intake may help to manage blood pressure (BP) and prevent complications associated with elevated BP. Objective: The objective of this study was to determine whether 4 wk of increased protein intake (∼25% compared with ∼15% of energy intake that isoenergetically...

Background Egg yolks can be a source of docosahexaenoic acid (DHA) and iron but are often associated with adverse consequences on plasma cholesterol. Objective Our goal was to investigate the effect of consumption of 4 egg yolks/wk on infant DHA status and hemoglobin, ferritin, and plasma...

Highlights Brain orexin/hypocretin cells are stimulated by dietary amino acids (AAs) AA sensing involves K-ATP channels and system-A transporters Nonessential AAs stimulate orexin/hypocretin cells more than essential AAs AA presence prevents glucose from blocking orexin/hypocretin cells...

Choline is a dietary component essential for normal function of all cells. It, or its metabolites, assures the structural integrity and signaling functions of cell membranes; it is the major source of methyl-groups in the diet (one of choline's metabolites, betaine, participates in the...