Research, all articles

Abstract Of the many possible hypotheses which explain the recent rise in childhood food allergy, the dual allergen exposure hypothesis has been the most extensively investigated. This chapter serves as a review and update on the prevention of food allergy, and focuses on recently...

Abstract Background: There is limited understanding of how maternal diet affects breastmilk food allergen concentrations, and whether exposure to allergens through this route influences the development of infant oral tolerance or sensitization. Objective: To investigate how maternal...

Abstract Background Food allergy naturally resolves in a proportion of food allergic children without intervention, however the underlying mechanisms governing the persistence or resolution of food allergy in childhood are not understood. Objectives This study aimed to define the innate...

Abstract Background The ideal age to introduce egg into the infant diet has been debated for the past 2 decades in the context of rising rates of egg allergy. Objective We sought to determine whether regular consumption of egg protein from age 4 to 6 months reduces the risk of IgE-mediated...

Abstract Background Evidence is accumulating that early consumption is more beneficial than is delayed introduction as a strategy for primary prevention of food allergy. However, allergic reactions caused by early introduction of such solid foods have been a problematic issue. We...

Abstract Epidemiological evidence suggests delayed introduction of egg may not protect against egg allergy in infants at risk of allergic disease. Objective To assess whether dietary introduction of egg between 4-6 months in infants at risk of allergy would reduce sensitization to egg...

ABSTRACT Importance Timing of introduction of allergenic foods to the infant diet may influence the risk of allergic or autoimmune disease, but the evidence for this has not been comprehensively synthesized. Objective To systematically review and meta-analyze evidence that timing of...

Background We previously reported the results of a randomized placebo-controlled study of egg oral immunotherapy (eOIT) in which 27.5% of subjects achieved sustained unresponsiveness (SU) after 2 years. Here we report the results of treatment through 4 years and long-term follow-up...

Background Several indicators suggest that food allergy in infants is common and possibly increasing. Few studies have used oral food challenge to measure this phenomenon at the population level. Objective To measure the prevalence of common IgE-mediated childhood food allergies in a...