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Allergy

Factors influencing adherence in a trial of early introduction of allergenic food

Perkin M, Logan K, Bahnson H, Marrs T et al.

Background

The Enquiring About Tolerance (EAT) study examined whether the early introduction of 6 allergenic foods from 3 months of age in exclusively breastfed infants prevented the development of food allergy. The intervention was effective in the per-protocol analysis for allergy to 1 or more foods and for egg and peanut individually, but only 42% of early introduction group (EIG) children met the per-protocol criteria.

Objective

Efficacy of the Enquiring About Tolerance (EAT) study among infants at high risk of developing food allergy

Perkin M, Logan K, Bahnson H, Marrs T et al.

Background
The Enquiring About Tolerance (EAT) study was a randomized trial of the early introduction of allergenic solids into the infant diet from 3 months of age. The intervention effect did not reach statistical significance in the intention-to-treat analysis of the primary outcome.

Objective
We sought to determine whether infants at high risk of developing a food allergy benefited from early introduction.

Effects of maternal dietary egg intake during early lactation on human milk ovalbumin concentration: a randomized controlled trial

Abstract

Background:

There is limited understanding of how maternal diet affects breastmilk food allergen concentrations, and whether exposure to allergens through this route influences the development of infant oral tolerance or sensitization.

Objective:

To investigate how maternal dietary egg ingestion during early lactation influences egg protein (ovalbumin) levels detected in human breastmilk.

Early life innate immune signatures of persistent food allergy

Abstract

Background

Food allergy naturally resolves in a proportion of food allergic children without intervention, however the underlying mechanisms governing the persistence or resolution of food allergy in childhood are not understood.

Objectives

This study aimed to define the innate immune profiles associated with egg allergy at one year of age, determine the phenotypic changes that occur with the development of natural tolerance in childhood and explore the relationship between early life innate immune function and serum vitamin D.

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