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Nutrient composition

Maternal Dietary Choline Status Influences Brain Grey and White Matter Development in Young Pigs



Choline is an essential nutrient that is pivotal to proper brain development. Research in animal models suggests that perinatal choline deficiency influences neuron development in the hippocampus and cortex, yet these observations require invasive techniques.


This study aimed to characterize the effects of perinatal choline deficiency on grey and white matter development using non-invasive neuroimaging techniques in the young pig.

A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults



We performed a systematic review, meta-analysis and meta-regression to determine if dietary protein supplementation augments resistance exercise training (RET)-induced gains in muscle mass and strength.

Data sources 

A systematic search of Medline, Embase, CINAHL and SportDiscus.

Eligibility criteria 

Only randomised controlled trials with RET ≥6 weeks in duration and dietary protein supplementation.

Delayed conception in women with low-urinary iodine concentrations: a population-based prospective cohort study


Study Question

Is iodine deficiency associated with decreased fecundability?

Summary Answer

Moderate to severe iodine deficiency is associated with a 46% decrease in fecundability.

What is Kanown Already

Iodine deficiency is common in women of childbearing age but its effect on fecundability has not been investigated.

Maternal choline supplementation during the third trimester of pregnancy improves infant information processing speed: a randomized, double-blind, controlled feeding study


Rodent studies demonstrate that supplementing the maternal diet with choline during pregnancy produces
life-long cognitive benefits for the offspring. In contrast, the two experimental studies examining cognitive
effects of maternal choline supplementation in humans produced inconsistent results, perhaps because of poor
participant adherence and/or uncontrolled variation in intake of choline or other nutrients.Weexamined the effects
of maternal choline supplementation during pregnancy on infant cognition, with intake of choline and other

Eggs early in complementary feeding increase choline pathway biomarkers and DHA: a randomized controlled trial in Ecuador



Choline status has been associated with stunting among young children. Findings from this study showed that an egg intervention improved linear growth by a length-for-age z score of 0.63.


We aimed to test the efficacy of eggs introduced early in complementary feeding on plasma concentrations of biomarkers in choline pathways, vitamins B-12 and A, and essential fatty acids.